Human Recombinant 4-1BB/CD137 Extracellular Domain

<strong>Human Recombinant 4-1BB/CD137 Extracellular Domain</strong>_x000D_ <strong>Catalog number:</strong> B2016979_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 45.2 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> 4-1BB Ligand Receptor, CDw137, ILA, TNFRSF9, Tumor Necrosis Factor Receptor Superfamily Member 9_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Han Y, Xie W, Song DG, Powell DJ Jr. Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells J Hematol Oncol. 2018 Jul 6;11(1):92._x000D_ 2: Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B Biochem Biophys Res Commun. 1998 Jan 26;242(3):613-20._x000D_ 3: Sica G, Chen L. Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy Arch Immunol Ther Exp (Warsz). 1999;47(5):275-9._x000D_ 4: Trüb M, Uhlenbrock F, Claus C, Herzig P, Thelen M, Karanikas V, Bacac M, Amann M, Albrecht R, Ferrara-Koller C, Thommen D, Rothschield S, Savic Prince S, Mertz KD, Cathomas G, Rosenberg R, Heinzelmann-Schwarz V, Wiese M, Lardinois D, Umana P, Klein C, Laubli H, Kashyap AS, Zippelius A. Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer J Immunother Cancer. 2020 Jul;8(2):e000238._x000D_ 5: Mikkelsen K, Harwood SL, Compte M, Merino N, Mølgaard K, Lykkemark S, Alvarez-Mendez A, Blanco FJ, Álvarez-Vallina L. Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies Front Immunol. 2019 Jul 31;10:1791._x000D_ 6: Wen T, Bukczynski J, Watts TH. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function J Immunol. 2002 May 15;168(10):4897-906._x000D_ 7: Kim HH, Kwack K, Lee ZH. Activation of c-jun N-terminal kinase by 4-1BB (CD137), a T cell co-stimulatory molecule Mol Cells. 2000 Jun 30;10(3):247-52._x000D_ 8: Bitra A, Doukov T, Wang J, Picarda G, Benedict CA, Croft M, Zajonc DM. Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling J Biol Chem. 2018 Jan 26;293(4):1317-1329._x000D_ 9: So EC, Khaladj-Ghom A, Ji Y, Amin J, Song Y, Burch E, Zhou H, Sun H, Chen S, Bentzen S, Hertzano R, Zhang X, Strome SE. NK cell expression of Tim-3: First impressions matter Immunobiology. 2019 May;224(3):362-370._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29980239">10: Han Y, Xie W, Song DG, Powell DJ Jr. Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells J Hematol Oncol. 2018 Jul 6;11(1):92. </a>_x000D_ _x000D_ <strong>Products Related to Human Recombinant 4-1BB/CD137 Extracellular Domain can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>