N3-C4-NHS ester
Product Specifications
UNSPSC Description
N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n3-c4-nhs-ester.html
Purity
99.34
Solubility
10 mM in DMSO
Smiles
O=C(ON1C(CCC1=O)=O)CCCCN=[N+]=[N-]
Molecular Weight
240.22
References & Citations
[1]Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126522/N3-C4-NHS-ester-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126522/N3-C4-NHS-ester-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
478801-48-8
Available Sizes
Curated Selection
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