TP0597850
TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM) . TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min) [1].
Product Specifications
CAS Number
[2642181-22-2]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tp0597850.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(CCCCNC([C@H](CCC(O)=O)N(C)C([C@H](CC(C)C)NC([C@H]1N(C[C@H](C1)N)C(CC[C@H](C(O)=O)NS(=O)(C2=CC=C(C=C2)NC(C3=CC=C(C=C3)C(N)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C41H57N9O13S
Molecular Weight
916.01
References & Citations
[1]Takeuchi T, et al. Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. J Med Chem. 2023 Jan 12;66 (1) :822-836.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-12; MMP-13; MMP-2
Available Sizes
Curated Selection
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