SEN12333

SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist. SEN12333 displays high affinity for the rat α7 nAChRs expressed in GH4C1 cells (K>i=260 nM) and acts as full agonist in functional Ca2+ flux studies (EC50=1.6 μM) . SEN 12333 is used for AD and schizophrenia research[1].

Product Specifications

CAS Number

[874450-44-9]

Product Name Alternative

WAY-317538

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sen12333.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2

Molecular Formula

C20H25N3O2

Molecular Weight

339.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Corinne Beinat, et al. The Recent Development of α7 Nicotinic Acetylcholine Receptor (nAChR) Ligands as Therapeutic Candidates for the Treatment of Central Nervous System (CNS) Diseases.Curr Pharm Des. 2016;22 (14) :2134-51.|[2]Renza Roncarati, et al. Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther. 2009 May;329 (2) :459-68.