HL-2
HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hl-2.html
Solubility
10 mM in DMSO
Smiles
COC1=NC=C(C=C1NS(=O)(C2=C(C=C(C=C2)F)F)=O)C3=CN4C(C5=NN=C(O5)C6=C(C=CC=C6)C(O)=O)=CN=C4C=C3
Molecular Formula
C28H18F2N6O6S
Molecular Weight
604.54
References & Citations
[1]Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022;61:116707.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143277/HL-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143277/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[2766352-49-0]
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