ANI-7
Product Specifications
Product Name Alternative
Prodigiosine (hydrochloride)
UNSPSC Description
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].
Target Antigen
Aryl Hydrocarbon Receptor; Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ani-7.html
Purity
98.13
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
ClC1=CC(/C(C#N)=C/C2=CC=CN2)=CC=C1Cl
Molecular Weight
263.12
References & Citations
[1]ilbert J, et al. (Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018 Feb;93(2):168-177.|[2]Baker JR, et al. Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro. ChemMedChem. 2018 Jul 18;13(14):1447-1458.|[3]Mark Tarleton, et al. Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. Medicinal Chemistry Communication. January 20112. (1):31-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117102/ANI-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117102/ANI-7-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
931417-26-4
Available Sizes
Curated Selection
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