PF-04822163
Product Specifications
UNSPSC Description
PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04822163.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=CC2=C([C@H]3CCC4=C3C=C(Cl)C=C4)N=CN=C12
Molecular Weight
340.80
References & Citations
[1]Humphrey J M, et al. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1[J]. MedChemComm, 2014, 5(9): 1290-1296.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120741/PF-04822163-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120741/
Clinical Information
No Development Reported
CAS Number
1798334-07-2
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