L-Pyroglutamic acid

L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE) [1].

Product Specifications

CAS Number

[98-79-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/_S_-5-oxopyrrolidine-2-carboxylic_acid.html

Purity

98.57

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CC1)NC1=O

Molecular Formula

C5H7NO3

Molecular Weight

129.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiménez-Arias D, et al. Lettuce plants treated with L-pyroglutamic acid increase yield under water deficit stress[J]. Environmental and experimental botany, 2019, 158: 215-222.|[2]Zhang Q, et al., Metabolomic profiling reveals serum L-pyroglutamic acid as a potential diagnostic biomarker for systemic lupus erythematosus. Rheumatology (Oxford) . 2021 Feb 1;60 (2) :598-606.