Isbogrel

Isbogrel (CV-4151) is a potent selective inhibitor of thromboxane A2 synthase. Isbogrel has oral activity and inhibits blood TXA2 generation with an ID50 value of 0.04 mg/kg[1].

Product Specifications

CAS Number

[89667-40-3]

Product Name Alternative

CV-4151

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/isbogrel.html

Solubility

10 mM in DMSO

Smiles

OC(CCCC/C=C(C1=CN=CC=C1)\C2=CC=CC=C2)=O

Molecular Formula

C18H19NO2

Molecular Weight

281.35

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]Z Terashita, et al. Effects of thromboxane A2 synthase inhibitors (CV-4151 and ozagrel), aspirin, and ticlopidine on the thrombosis caused by endothelial cell injury. Thromb Res. 1995, 77, 5.