Actinonin

Actinonin ((-) -Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

Product Specifications

CAS Number

[13434-13-4]

Product Name Alternative

(-) -Actinonin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aminopeptidase; Antibiotic; Apoptosis; Bacterial; MMP

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/actinonin.html

Purity

98.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N1[C@H](CO)CCC1)=O)C(C)C)[C@H](CCCCC)CC(NO)=O

Molecular Formula

C19H35N3O5

Molecular Weight

385.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee MD, et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest. 2004 Oct;114 (8) :1107-16.|[2]Chen DZ, et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39 (6) :1256-62.|[3]Wahl, R.C., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa) . Bioorganic & Medicinal Chemistry Letters 5 (4), 349-352 (1995) .|[4]Duke SO, et al. Modes of action of microbially-produced phytotoxins. Toxins (Basel) . 2011 Aug;3 (8) :1038-64.|[5]Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378 (Pt 2) :383-9.