Human LY75 / CD205 Protein, His Tag
Human LY75, His Tag (LY5-H52H3) is expressed from human 293 cells (HEK293) . It contains AA Ser 28 - Asp 1666 (Accession # O60449-1) .
Product Specifications
Background
Lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 190.7 kDa. The protein migrates as 200-230 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
O60449-1
Expression Region
Ser 28 - Asp 1666
Host
HEK293
Target
LY75
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
190.7 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/LY5-H52H3.pdf
Species
Human
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2103586-01 5x 96 Tests
Mouse Dipeptidyl Peptidase 9 (DPP9) Antibody Pair Kit (with Standard)
Ask
View Details MBS2103586-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)
Mouse Dipeptidyl Peptidase 9 (DPP9) Antibody Pair Kit (with Standard)
Ask
View Details 
MBS2103586-03 10x 96 Tests
Mouse Dipeptidyl Peptidase 9 (DPP9) Antibody Pair Kit (with Standard)
Ask
View Details MBS2103586-04 10x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 10x 96 Tests)
Mouse Dipeptidyl Peptidase 9 (DPP9) Antibody Pair Kit (with Standard)
Ask
View Details 