Proxyfan

Proxyfan is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].

Product Specifications

CAS Number

[177708-09-7]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/proxyfan.html

Purity

99.33

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

C1(CCCOCC2=CC=CC=C2)=CNC=N1

Molecular Formula

C13H16N2O

Molecular Weight

216.28

References & Citations

[1]X Ligneau, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50. |[2]R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167 (5) :1099-110.