Vaccarin

Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis[1][2][3].

Product Specifications

CAS Number

[53452-16-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Akt; AMPK; ERK; JNK; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vaccarin.html

Purity

98.47

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O)C(O)=C14

Molecular Formula

C32H38O19

Molecular Weight

726.63

Precautions

H315, H319

References & Citations

[1]Xie F, et al. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Mol Med Rep. 2015 Jul;12 (1) :1131-6.|[2]Lei Y, et al. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway. Eur J Pharmacol. 2019 May 15;851:13-24.|[3]Liu Y, et al. Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-κB and MAPK signaling pathways. J Cell Physiol. 2019 Aug;234 (8) :13832-13842.