FPFT-2216

FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α) . FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2].

Product Specifications

CAS Number

[2367619-87-0]

UNSPSC

12352005

Target

Casein Kinase; Molecular Glues; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fpft-2216.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O

Molecular Formula

C12H12N4O3S

Molecular Weight

292.32

References & Citations

[1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.|[2]Gemechu Y, et al. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018;115 (46) :11802-11807.