MGD-28
Product Specifications
UNSPSC Description
MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research[1].
Target Antigen
Casein Kinase; IKZF Family
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Immunology/Inflammation;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mgd-28.html
Smiles
CN(N(C1C(NC(CC1)=O)=O)C2=O)CC(C2=CC=C3)=C3NCC(C=C4)=CC=C4CN(CC5)CCN5C6=CC(F)=C(C#N)C=C6
Molecular Weight
595.67
References & Citations
[1]Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17(1): 77.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168615/MGD-28-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168615/
Clinical Information
No Development Reported
CAS Number
2991818-13-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
