Perfluoroenanthic acid

Perfluoroenanthic acid (Perfluoroheptanoic acid) is a type of perfluoroalkyl substance (PFAS) that can negatively impact the development of seminiferous tubules and m6A RNA methylation in the testes of offspring mice when exposed during pregnancy, consequently disrupting spermatogenesis and leading to reproductive toxicity. Perfluoroenanthic acid alters the morphology of dendritic spines and synaptic formation in primary cortical neuron cultures, enhancing neuronal activity and synaptic transmission, and increasing the expression of excitatory synapse-related proteins Synaptophysin and PSD95[1][2].

Product Specifications

CAS Number

[375-85-9]

Product Name Alternative

Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA

UNSPSC

12352211

Hazard Statement

H302, H314

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

Molecular Formula

C7HF13O2

Molecular Weight

364.06

Precautions

H302, H314

References & Citations

[1]Yijie Zhou, et al. Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice. Ecotoxicol Environ Saf. 2023 Jul 15:260:115072.|[2]Moon Yi Ko, et al. Differential regulations of neural activity and survival in primary cortical neurons by PFOA or PFHpA. Chemosphere. 2024 Mar:352:141379.