Hardwickiic acid

Hardwickiic acid ((-) -Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].

Product Specifications

CAS Number

[1782-65-6]

Product Name Alternative

(-) -Hardwickiic acid; (-) -Hardwikiic acid

UNSPSC

12352005

Target

Parasite; Sodium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hardwickiic-acid.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3

Molecular Formula

C20H28O3

Molecular Weight

316.43

References & Citations

[1]Cai S, et al. (-) -Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1716-1728. |[2]Bandara BM, et al. Isolation and Insecticidal Activity of (-) -Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53 (6) :575. |[3]Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62 (4) :354-9.