Estradiol-d3

Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

Product Specifications

CAS Number

[79037-37-9]

Product Name Alternative

β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3

UNSPSC

12352005

Hazard Statement

H340, H350, H361

Target

Endogenous Metabolite; Estrogen Receptor/ERR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Cancer

Purity

98.60

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 20mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC([2H])([2H])[C@]2([2H])O)([H])[C@@]3([H])[C@](C4=C(C=C(O)C=C4)CC3)([H])CC1

Molecular Formula

C18H21D3O2

Molecular Weight

275.40

Precautions

H340, H350, H361

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160 (1) :6-12.|[3]Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12 (7) :2549-54.; Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336 (2) :293-306.; Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37 (1) :133.; Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17 (5) :1848-59.