Cyclamidomycin

Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml) [1][2].

Product Specifications

CAS Number

[35663-85-5]

Product Name Alternative

Desdanine; Pyracrimycin A

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Antibiotic; Bacterial; Fungal; Oxidative Phosphorylation; Pyruvate Kinase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclamidomycin.html

Smiles

NC(/C=C/C1=NCCC1)=O

Molecular Formula

C7H10N2O

Molecular Weight

138.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kazuhiko Otoguro, et al. Promising lead compounds for novel antiprotozoals. J Antibiot (Tokyo) . 2010 Jul;63 (7) :381-4. |[2]S Takahashi, et al. A new antibiotic, cyclamidomycin. J Antibiot (Tokyo) . 1971 Dec;24 (12) :902-3.