Aphadilactone C

Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1].

Product Specifications

CAS Number

[1522004-70-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Acyltransferase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aphadilactone-c.html

Solubility

10 mM in DMSO

Smiles

CC(C[C@H]1/C=C(C)/CCC[C@@]2(C(OC(C)3C)=CC3=O)C4=C(OC(C)(C4=O)C)[C@H](CC2)CCC/C(C)=C/[C@@H]5CC(C)=CC(O5)=O)=CC(O1)=O

Molecular Formula

C40H52O8

Molecular Weight

660.84

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jia Liu, et al. Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant. J Org Chem. 2014 Jan 17;79 (2) :599-607.