Bavarostat
Bavarostat (EKZ-001) is a BBB-penetrable and selective HDAC6 inhibitor (IC50: 0.06 μM) . Bavarostat modulates tubulin acetylation selectively over histone acetylation. Bavarostat can be used for research of cancers and central nervous system (CNS) disorders[1].
Product Specifications
CAS Number
[2134109-20-7]
Product Name Alternative
EKZ-001
UNSPSC
12352005
Target
HDAC; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bavarostat.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NO)C1=CC=C(CN(C)CC2(C3)CC4CC3CC(C4)C2)C(F)=C1
Molecular Formula
C20H27FN2O2
Molecular Weight
346.44
References & Citations
[1]Strebl MG, et al. HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. ACS Cent Sci. 2017 Sep 27;3 (9) :1006-1014.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Available Sizes
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