BTT-266
Product Specifications
UNSPSC Description
BTT-266 is an antagonist forcalcium channel, through suppression of the CaVα1-AID-CaVβ3 interaction, with a Ki of 1.4 μM. BTT-266 modulates the activation of voltage-dependent CaV2.2. BTT-266 exhibits analgesic efficacy against neuropathic pain in rats model[1].
Target Antigen
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/btt-266.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C(N2N=C(CC2C3=CN(C4=CC=CC=C4)N=C3C5=CC=C(C)C=C5)C6=CC=C(OC)C=C6)=O)=C1)O
Molecular Weight
556.61
References & Citations
[1]Chen X, et al., Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115597/BTT-266-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115597/
Clinical Information
No Development Reported
CAS Number
2413939-89-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7006885-01 0.02 mg
Recombinant Human E3 ubiquitin-protein ligase MARCH8 (MARCH8)
Ask
View Details 
MBS7006885-03 5x 0.1 mg
Recombinant Human E3 ubiquitin-protein ligase MARCH8 (MARCH8)
Ask
View Details