QM385
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].
Product Specifications
CAS Number
[2093421-02-2]
Product Name Alternative
Y-39983 (free base)
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/qm385.html
Purity
99.48
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC(N2N=CC(C(N3CCN(CC(F)(F)F)CC3)=O)=C2C)=NN4C1=CC=C4
Molecular Formula
C17H18F3N7O2
Molecular Weight
409.37
References & Citations
[1]Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563 (7732) :564-568.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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