Halenaquinone

Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells[1][2][3].

Product Specifications

CAS Number

[86690-14-4]

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/halenaquinone.html

Smiles

O=C1CC[C@@](C2=C3OC=C21)(C)C4=C(C3=O)C=C(C(C=CC5=O)=O)C5=C4

Molecular Formula

C20H12O5

Molecular Weight

332.31

References & Citations

[1]Deborah M. Roll, et al. Halenaquinone, a pentacyclic polyketide from a marine sponge. : Journal of the American Chemical Society.Vol 105/Issue 19.|[2]Fujiwara H, et al. Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells. Eur J Pharmacol. 2001;413 (1) :37-45. |[3]Tsukamoto S, et al. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett. 2014;24 (22) :5315-5317.