MONNA

MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions[1].

Product Specifications

CAS Number

[1572936-83-4]

UNSPSC

12352005

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/monna.html

Purity

99.87

Solubility

DMSO : 55.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CC([N+]([O-])=O)=CC=C1NC2=CC(OC)=C3C=CC=CC3=C2

Molecular Formula

C18H14N2O5

Molecular Weight

338.31

References & Citations

[1]Oh SJ, et al. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol Pharmacol. 2013 Nov;84 (5) :726-35.