ZA3-Ep10

ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.

Product Specifications

CAS Number

[2090299-48-0]

UNSPSC

12352211

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/za3-ep10.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CCN(CC(CCCCCCCC)O)CCN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)NCC[N+](C)(CCCS(=O)([O-])=O)C

Molecular Formula

C66H138N6O9S

Molecular Weight

1191.90

References & Citations

[1]Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids. WO2017201076A1|[2]Melamed JR, Hajj KA, Chaudhary N, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022;341:206-214. |[3]Melamed JR, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022 Jan;341:206-214.|[4]Miller JB, et al. Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angew Chem Int Ed Engl. 2017 Jan 19;56 (4) :1059-1063.|[5]He S, et al. Zwitterionic materials for nucleic acid delivery and therapeutic applications. J Control Release. 2024 Jan;365:919-935.