Centmitor-1

Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint[1].

Product Specifications

CAS Number

[331749-88-3]

Product Name Alternative

Cent-1

UNSPSC

12352005

Hazard Statement

H302-H410

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/centmitor-1.html

Smiles

O=C1C2=C(N(CC(N/N=C/C3=CC=C(C(Br)=C3)O)=O)C4=C1C=CC=C4)C=CC=C2

Molecular Formula

C22H16BrN3O3

Molecular Weight

450.28

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Jenni H E Mäki-Jouppila, et al. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 May;13 (5) :1054-66.