MRS4833

MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].

Product Specifications

CAS Number

[2801627-78-9]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mrs4833.html

Smiles

O[C@@]1(C2=CC=C(C3=CC(C(O)=O)=CC4=C3C=CC(C5=CC=C(C=C5)C(F)(F)F)=C4)C=C2)[C@]6([H])C[C@@]1([H])CNC6

Molecular Formula

C30H24F3NO3

Molecular Weight

503.51

References & Citations

[1]Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66 (13) : 9076-9094.