MLS-0053105
MLS-0053105, a chloromaleimide, is a selective BFL-1 inhibitor with an IC50 of 0.4 µM for Bfl-1/F-Bid. MLS-0053105 shows over 10 times less potent inhibition of Bcl-W, Bcl-2, and Bcl-XL and no activity against Bcl-B and Mcl-1[1].
Product Specifications
CAS Number
[370572-36-4]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mls-0053105.html
Smiles
O=C1C(Cl)=C(N2CCN(CC2)C)C(N1C3=CC=C(C(Cl)=C3)Cl)=O
Molecular Formula
C15H14Cl3N3O2
Molecular Weight
374.65
References & Citations
[1]Dayong Zhai, et al. High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. J Biomol Screen. 2012 Mar;17 (3) :350-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-W; Bcl-xL; Bfl-1
Curated Selection
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