Sumatriptan

Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research[1][2][3][4].

Product Specifications

CAS Number

[103628-46-2]

Product Name Alternative

GR 43175 free base

UNSPSC

12352005

Hazard Statement

H361, H412

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sumatriptan.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O

Molecular Formula

C14H21N3O2S

Molecular Weight

295.41

Precautions

H361, H412

References & Citations

[1]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43 (5) :776-98.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163 (1) :133-6. |[3]Razzaque Z, et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol. 1999 Jan;47 (1) :75-82.|[4]Bates EA, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb;30 (2) :170-8.