JMS-175-2
Product Specifications
UNSPSC Description
JMS-175-2 is a potent agonist of BRCC36 isopeptidase complex (BRISC), with the IC50 of 3.8 μM. JMS-175-2 plays an important role in Type I interferon-mediated diseases[1].
Target Antigen
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jms-175-2.html
Smiles
ClC1=CC=CC(Cl)=C1C(N2C=C(NC(C3=C(Cl)C=CC=C3Cl)=O)C(C(NC4CCNCC4)=O)=N2)=O
Molecular Weight
555.24
References & Citations
[1]"Francesca Chandler, et al. Molecular glues that inhibit specific Zn2+-dependent DUB activity and inflammation. bioRxiv
[Preprint]. 2024 Sep 7:2024.09.07.611787."
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168219/JMS-175-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168219/
Clinical Information
No Development Reported
CAS Number
3042887-70-4
Curated Selection
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