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Anti-FOLH1 / PSMA (Prostate Epithelial Marker)(FOLH1/2121)

Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

Cell growth-inhibiting gene 27 protein (GIG27); Folylpoly-gamma-glutamate carboxypeptidase (FGCP); Glutamate carboxylase II (GCPII); N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1 or NAALADase); Prostate-specific membrane antigen (PSM or PSMA); Pteroylpoly-gamma-glutamate carboxypeptidase

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

FOLH1

Gene ID

2346

NCBI Gene ID

654487

UniProt

Q04609

Cellular Locus

Plasma membrane

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)

Target Antigen

FOLH1 | PSMA

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

FOLH1/2121

Conjugation

Purified, with BSA

Disease

Tumor

Source

Animal

Positive Control

LNCap or HepG2 cells. Prostate Carcinoma.

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

100 kDa

Additionnal Information

For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

Shipping Conditions

Room temperature

Storage Conditions

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/7638236/datasheet/bnub2121-100.pdf

Product MSDS

https://cdn.gentaur.com/products/37/7638236/msds/bnub2121-100.pdf

CAS Number

9007-83-4

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