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Anti-PTEN (Tumor Suppressor Oncoprotein) (PTEN/2110)

PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

BZS; DEC; GLM2; MHAM; Mutated in Multiple Advanced Cancers 1 (MMAC1); MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Phosphatase and Tensin Homolog; Phosphatase and tensin like protein; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase; PTEN; PTEN1; TEP1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

PTEN

Gene ID

5278

NCBI Gene ID

500466; 729457

UniProt

P60484

Cellular Locus

Nucleus & cytoplasm

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant full-length human PTEN protein

Target Antigen

PTEN

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

PTEN/2110

Conjugation

Purified, BSA-free

Source

Animal

Applications

IHC, FFPE (verified)

Validated Applications

IHC,FFPE

Field of Research

Signal transduction, Tumor suppressors

Positive Control

MCF-7 or HeLa Cells. Prostate, Breast, Liver, Renal Carcinoma.

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

55 kDa

Additionnal Information

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user

Shipping Conditions

Room temperature

Storage Conditions

-35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/7638169/datasheet/bnum2110-50.pdf

Product MSDS

https://cdn.gentaur.com/products/37/7638169/msds/bnum2110-50.pdf

CAS Number

9007-83-4

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