Gramine

Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].

Product Specifications

CAS Number

[87-52-5]

Product Name Alternative

Donaxine

UNSPSC

12352005

Hazard Statement

H302+H312

Target

Adiponectin Receptor; Reverse Transcriptase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Gramine.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CN(C)CC1=CNC2=C1C=CC=C2

Molecular Formula

C11H14N2

Molecular Weight

174.25

Precautions

H302+H312

References & Citations

[1]Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8 (5) :e63354.|[2]Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo) . 2018;64 (1) :68-74.