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Anti-BTLA(BTLA/1528)

B and T lymphocyte attenuator (BTLA) is a member of the CD28 Ig superfamily of inhibitory co-receptors, along with CTLA-4 and PD-1. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family receptors. Rather, it is engaged by herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily, leading to an inhibited immune response. It also plays a role in immune tolerance. BTLA is expressed on most CD4 and CD8 T cells, B cells, macrophages, dentritic cells, and NK cell. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

BTLA; B and T lymphocyte associated protein; B and T lymphocyte attenuator; CD272

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

BTLA

Gene ID

151888

NCBI Gene ID

445162

UniProt

Q7Z69

Cellular Locus

Plasma membrane

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant full-length human BTLA protein

Target Antigen

BTLA | CD272

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

BTLA/1528

Conjugation

Purified, BSA-free

Source

Animal

Field of Research

Immunology

Positive Control

Human lymph node or MDAMB468 xenograft.

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

33 kDa

Additionnal Information

For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

Shipping Conditions

Room temperature

Storage Conditions

-35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/7631091/datasheet/bnum1528-50.pdf

Product MSDS

https://cdn.gentaur.com/products/37/7631091/msds/bnum1528-50.pdf

CAS Number

9007-83-4

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