SMARCA2 degrader-17
Product Specifications
UNSPSC Description
SMARCA2 degrader-17 (Compound 1) is a SMARCA2 degrader. SMARCA2 degrader-17 shows synergistic anti-proliferation effects with Adagrasib (HY-130149) in cancer cells. SMARCA2 degrader-17 inhibits tumor growth[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-degrader-17.html
Smiles
OC1=C(C=CC=C1)C2=NN=C3NC[C@](CN([C@H]4CN(CC4)C[C@H](C)OC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=C5)CC9)([H])N9C3=C2
Molecular Weight
891.09
References & Citations
[1]Koichi Ito, et al. Improved treatment of cancers using combinations of smarca2 degraders and kras targeting therapies. Patent. WO2024076985A2
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159607/SMARCA2-degrader-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159607/
Clinical Information
No Development Reported
CAS Number
2755761-78-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
OR1049749-01 100 mg
1- ((2R,6S) -6- (((tert-Butyldiphenylsilyl) oxy) methyl) morpholin-2-yl) -5-methylpyrimidine-2,4 (1H,3H) -dione
Ask
View Details 
OR1049749-02 250 mg
1- ((2R,6S) -6- (((tert-Butyldiphenylsilyl) oxy) methyl) morpholin-2-yl) -5-methylpyrimidine-2,4 (1H,3H) -dione
Ask
View Details 
OR1049749-03 1 g
1- ((2R,6S) -6- (((tert-Butyldiphenylsilyl) oxy) methyl) morpholin-2-yl) -5-methylpyrimidine-2,4 (1H,3H) -dione
Ask
View Details 