MJP6412
Product Specifications
UNSPSC Description
MJP6412 is a potent degrader histone acetyltransferases p300/CBP, with DC50 of 1.6 and 1.2 nM for p300 and CBP, respectively. MJP6412 plays an important role in cancer research[1].
Target Antigen
Histone Acetyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mjp6412.html
Smiles
O=C(CCC1N(C(C2=C3C=CC(N4CCC(CC4)OC5=CC=C(C=C5)NC(CO[C@H]6CC[C@H](N7C([C@H]8N(C9=CC(F)=C(F)C=C9)C(CCC8)=O)=NC%10=CC(C%11=C(C)ON=C%11C)=CC=C7%10)CC6)=O)=C2)=O)C3=O)NC1=O
Molecular Weight
1009.06
References & Citations
[1]Mengjun Ma, et al. Discovery of a Highly Potent PROTAC Degrader of p300/CBP Proteins for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2024 Sep 29.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168201/MJP6412-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168201/
Clinical Information
No Development Reported
Curated Selection
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