TPh A
TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1].
Product Specifications
CAS Number
[21306-65-0]
Product Name Alternative
Triphenyl Compound A
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tph-a.html
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=[S](/N=[S](C(C=C1)=CC=C1OCC2=CC=CC=C2)\C)(C(C=C3)=CC=C3C)=O
Molecular Formula
C21H21NO3S2
Molecular Weight
399.53
References & Citations
[1]Isao Miyazaki, et al. A Small-Molecule Inhibitor Shows That Pirin Regulates Migration of Melanoma Cells. Nat Chem Biol. 2010 Sep;6 (9) :667-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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