26-Deoxyactein

26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels[1].

Product Specifications

CAS Number

[264624-38-6]

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor; ERK

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/27-deoxyactein.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@]3([H])[C@@]4(C[C@H]([C@@]1([C@]5([H])[C@](O[C@]6([C@@]7([H])[C@](O7)(CO6)C)C[C@H]5C)([H])C2)C)OC(C)=O)[C@@]8([C@](CC3)([H])C(C)([C@H](CC8)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O)O)O)C)C4

Molecular Formula

C37H56O10

Molecular Weight

660.83

References & Citations

[1]Suh KS, et al. 27-Deoxyactein prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular damage in MC3T3-E1 osteoblastic cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018 May 12;53 (6) :561-570.|[2]Chen SN, et al. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. J Nat Prod. 2002;65 (4) :601-605.