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PROTAC α-synuclein degrader 6

Product Specifications

UNSPSC Description

PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research (Blue:ubiquitin E3 ligase cereblon ligand (HY-14658), Black: linker (HY-128803); Pink: Ligand for target protein (HY-151035))[1].

Target Antigen

PROTACs; Tau Protein; α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling;PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/protac-α-synuclein-degrader-6.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC4=CC=C(C(S5)=NC6=C5C=C(C)C=C6)C=C4)=O)=C3C1=O

Molecular Weight

729.80

References & Citations

[1]Wentao Zhu, et al. Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates. J Med Chem. 2024 Feb 14.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-157839/PROTAC-α-synuclein-degrader-6-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-157839/PROTAC-α-synuclein-degrader-6-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

3032208-24-2

Available Sizes

Curated Selection

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