OUL245

OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM) . OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1].

Product Specifications

CAS Number

[1023814-45-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/oul245.html

Solubility

10 mM in DMSO

Smiles

C1=CC2=C(C=C1O)SC3=NN=CN23

Molecular Formula

C8H5N3OS

Molecular Weight

191.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4.