BX430

BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

Product Specifications

CAS Number

[688309-70-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Calcium Channel; P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bx430.html

Purity

99.21

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CN=C1)NC2=C(Br)C=C(C(C)C)C=C2Br

Molecular Formula

C15H15Br2N3O

Molecular Weight

413.11

Precautions

H302

References & Citations

[1]Ase AR, et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87 (4) :606-16. |[2]Sophocleous RA, et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol. 2020 Feb 4.