MAP855
MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM) . MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2[1].
Product Specifications
CAS Number
[1660107-77-6]
UNSPSC
12352005
Target
ERK; MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/map855.html
Purity
98.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC2=C(C3=CC(C4=C(C=C(C=C4)OC5=NC=CC=N5)Cl)=C(F)C=C3N=C2)N1[C@]6([H])[C@H](CN(CC6)C(CO)=O)F
Molecular Formula
C28H23ClF2N6O3
Molecular Weight
564.97
References & Citations
[1]Poddutoori R, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022;65 (5) :4350-4366.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; MEK1
Available Sizes
Curated Selection
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