APTSTAT3-9R

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity[1].

Product Specifications

UNSPSC

12352209

Target

STAT

Type

Peptides

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aptstat3-9r.html

Purity

98.82

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CO)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@@H](CC%13=CC=C(C=C%13)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%15=CNC=N%15)N

Molecular Formula

C223H330N80O51

Molecular Weight

4947.51

References & Citations

[1]Daejin Kim, et al. A Specific STAT3-binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling. Cancer Res. 2014 Apr 15;74 (8) :2144-51.