Methisazone

Methisazone (Marboran) is an antiviral agent that works by inhibiting mRNA and protein synthesis. Methisazone is also a SARS-CoV-2 (COVID-19) inhibitor. Methisazone is mainly used in pox viruses[1].

Product Specifications

CAS Number

[1910-68-5]

Product Name Alternative

Marboran

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Orthopoxvirus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/methisazone.html

Purity

98.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=C(/C1=N/NC(N)=S)C=CC=C2)C

Molecular Formula

C10H10N4OS

Molecular Weight

234.28

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Bhumi Shah, et al. In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. Life Sci. 2020 Jul 1;252:117652.|[2]Smee DF, et, al. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19 (3) :115-24.|[3]Quenelle D C, et al. In vitro and in vivo evaluation of isatin-β-thiosemicarbazone and marboran against vaccinia and cowpox virus infections[J]. Antiviral Research, 2006, 71 (1) : 24-30.