N-Ethyl-N-nitrosourea
Product Specifications
UNSPSC Description
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/n-ethyl-n-nitrosourea.html
Smiles
O=NN(CC)C(N)=O
Molecular Weight
117.11
References & Citations
[1]Hou X, et al. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis. J Inflamm Res. 2024 Feb 7;17:777-790.|[2]Goth R, et al. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W019815/N-Ethyl-N-nitrosourea-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W019815/
Clinical Information
No Development Reported
CAS Number
759-73-9
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