Endoxifen

Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].

Product Specifications

CAS Number

[110025-28-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332, H361, H413

Target

Cytochrome P450; Drug Metabolite; Estrogen Receptor/ERR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Endoxifen.html

Concentration

10mM

Purity

99.42

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCNC)C=C3

Molecular Formula

C25H27NO2

Molecular Weight

373.49

Precautions

H302, H312, H332, H361, H413

References & Citations

[1]Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park) . 2009 Dec;23 (14) :1233-4, 1236.|[2]Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69 (5) :1722-7.