4,4'-Dihydroxybenzophenone

4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801) ) . 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna[1][2][3].

Product Specifications

CAS Number

[611-99-4]

UNSPSC

12352200

Hazard Statement

H315, H317, H319, H335

Target

Drug Intermediate; Ser/Thr Protease

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-4-dihydroxybenzophenone.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C2=C(C(C1=CC=C(O)C=C1)=O)C=CC(=C2)O

Molecular Formula

C13H10O3

Molecular Weight

214.22

Precautions

H315, H317, H319, H335

References & Citations

[1]Ma J, et al. Health risks posed by environmental benzophenone-type ultraviolet filters (BP-UVFs) : An investigation into the binding of BP-UVFs to trypsin and their adverse effects. J Hazard Mater. 2023 Oct 5;459:132231. |[2]Han J, et al. Acute toxicity and ecological risk assessment of 4,4'-dihydroxybenzophenone, 2,4,4'-trihydroxybenzophenone and 4-MBC in ultraviolet (UV) -filters. PLoS One. 2021 Apr 8;16 (4) :e0249915. |[3]Morgan LR, et al. Design, synthesis, and anticancer properties of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone and analogues. J Med Chem. 2003 Oct 9;46 (21) :4552-63.