α-Methylserotonin

α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan. α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].

Product Specifications

CAS Number

[304-52-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/α-methylserotonin.html

Purity

95.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |Methanol : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC2=C(NC=C2CC(C)N)C=C1

Molecular Formula

C11H14N2O

Molecular Weight

190.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274 (2) :H650-4.|[2]Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119 (3) :821-33.|[3]Edwards E, et al. (+/-) -1- (2,5-Dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31 (7) :615-21.|[4]Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119 (3) :821-33.|[5]Edwards E, et al. (+/-) -1- (2,5-Dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31 (7) :615-21.