L-Norvaline

L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease[1][2].

Product Specifications

CAS Number

[6600-40-4]

Product Name Alternative

Norvaline

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Arginase; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-norvaline.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](CCC)C(O)=O

Molecular Formula

C5H11NO2

Molecular Weight

117.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Polis B, et al., L-Norvaline, a new therapeutic agent against Alzheimer's disease. Neural Regen Res. 2019 Sep;14 (9) :1562-1572.|[2]Javrushyan H, et al., Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Exp Mol Pathol. 2022 Jun;126:104763.